Near the end of 1801, his first year as president of the United States, Thomas Jefferson got a letter from Robert Patterson, professor of mathematics at the University of Pennsylvania, containing a page encrypted according to a new method. Patterson described his cryptosystem in detail, and boasted that without the key — which he didn't provide — decryption of his message would "defy the united ingenuity of the whole human race".
After more than 200 years, the code was finally broken by Dr. Lawren Smithline, a mathematician at the Center for Communications Research in Princeton, N.J., using a technique originally developed for biological sequence comparison.
This could be the premise for a new Dan Brown novel, if Patterson's message were sufficiently bizarre and consequential.
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