I was a little surprised to encounter the neolexeme embiggen in a perfectly serious Economist report about Ascension Island:
If a future turn of events in Africa was seen as requiring the island's military role to be embiggened and its facilities rendered much more secure, it might be convenient if the islanders had no legal right to remain where they were.
It is well known that embiggen was coined by Dan Greaney for an episode of The Simpsons, and Wikipedia reports that it "has seen use in several scientific publications" already. I wonder if it might really be taking off as a mainstream item of vocabulary.
That might put Dan Greaney into the very select club of people who invented words that make it into major dictionaries. A club containing him and very few others, such as the fellow Simpsons writer David S. Cohen ([now known as David X. Cohen, as commenters below point out] who coined cromulent for a Simpsons episode), Robert Heinlein (who coined grok in Stranger in a Strange Land), and (I blush modestly to confess) also me. I coined the term eggcorn, which has made it to the OED, as well as two words that are likely to make it in the future: the widely used linguistic technical term unaccusative, and the scientific term vortensity (designed to order for some Santa Cruz astronomers, and introduced in J. C. B. Papaloizou and Douglas N. C. Lin, "Nonaxisymmetric instabilities in thin self-gravitating rings and disks", Astrophysical Journal, Part 1, 344 [Sept. 15, 1989], 645-668; it now gets some 1300 Google hits).